Aging impairs hippocampus-dependent long-term memory for object location in mice
نویسندگان
چکیده
منابع مشابه
HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner.
Transcription of genes required for long-term memory not only involves transcription factors, but also enzymatic protein complexes that modify chromatin structure. Chromatin-modifying enzymes, such as the histone acetyltransferase (HAT) CREB (cyclic-AMP response element binding) binding protein (CBP), are pivotal for the transcriptional regulation required for long-term memory. Several studies ...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2012
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2011.07.007